生物活性

• 描述Tauroursodeoxycholate Sodium is a water-soluble bile acid used in the treatment of gallstones and cirrhosis. Tauroursodeoxycholate (TUDC) is well known to protect against glycochenodeoxycholate (GCDC)-induced apoptosis in rat hepatocytes. While GCDC upregulated the expression of several pro-inflammatory genes, co-perfusion with TUDC increased the expression of pro-proliferative and anti-apoptotic p53 target genes^[3]. After the induction of colitis for 24h, the mice were administrated orally with tauroursodeoxycholate (20, 40 and 60mg/kg) and sulfasalazine (500mg/kg) by gavage for 7 consecutive days. Treatment with different doses of tauroursodeoxycholate (20, 40 and 60mg/kg) significantly improved the body weight change, decreased the macroscopic and histopathological scores. Compared with the model group, the accumulation of MPO (myeloperoxidase) activity, the colonic tissue levels of IL-1β, IFN-γ and TNF-α were significantly reduced in the tauroursodeoxycholate treated groups. Moreover, tauroursodeoxycholate assuaged the symptoms of colitis^[4]. Tauroursodeoxycholate (360 μ mol / kg, i.v.) significantly inhibited the decrease of bile flow and increased the activities of serum alkaline phosphatase, leucine aminopeptidase and alanine aminotransferase, as well as the concentrations of cholesterol, phospholipids and bile acids in rats with bile obstruction induced by phalloidin^[5].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT03127514	Amyotrophic Lateral Sclerosis ... more >> Motor Neuron Disease Neuromuscular Diseases Neurodegenerative Diseases Spinal Cord Diseases TDP-43 Proteinopathies Nervous System Diseases Central Nervous System Diseases Collapse <<	Phase 2	Recruiting	May 2019	-
  NCT00771901	-	-	Completed	-	-
  NCT03533257	Alzheimer Disease	Phase 2	Recruiting	September 1, 2020	United States, Illinois ... more >> Rush University Medical Center Recruiting Chicago, Illinois, United States, 60612 Contact: Judy Phillips    312-942-0050    Judy_Phillips@rush.edu    United States, Kansas University of Kansas Clinical Research Center Recruiting Fairway, Kansas, United States, 66205 Contact: KUMC Recruitment Division    913-588-0555    KUAMP@kumc.edu    United States, Massachusetts Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Alison J McManus, DNP    617-643-4848    ajmcmanus@mgh.harvard.edu    Contact: John Ernandez    617-643-4047    jernandez@partners.org    United States, New Jersey Rowan University Not yet recruiting Stratford, New Jersey, United States, 08084 Contact: Lauren Fedor    856-566-6003    fedor@rowan.edu    United States, New York Mount Sinai Alzheimer's Disease Research Center Not yet recruiting New York, New York, United States, 10029 Contact: Caroline Meuser    212-659-8885    caroline.meuser@mssm.edu    Columbia University Recruiting New York, New York, United States, 10032 Contact: Ruth Tejeda    212-305-7661    rbt41@cumc.columbia.edu    United States, Pennsylvania Penn Memory Center Recruiting Philadelphia, Pennsylvania, United States, 19104 Contact: Laura Schankel    215-349-8727    laura.schankel@pennmedicine.upenn.edu Collapse <<

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• 参考文献

• [1] Alpini G, Kanno N, et al. Tauroursodeoxycholate inhibits human cholangiocarcinoma growth via Ca2+-, PKC-, and MAPK-dependent pathways. Am J Physiol Gastrointest Liver Physiol. 2004 Jun;286(6):G973-82.

  [2] Milkiewicz P, Roma MG, et al. Effect of tauroursodeoxycholate and S-adenosyl-L-methionine on 17beta-estradiol glucuronide-induced cholestasis. J Hepatol. 2001 Feb;34(2):184-91.

  [3] Paluschinski M, Castoldi M, Schöler D, Bardeck N, Oenarto J, Görg B, Häussinger D. Tauroursodeoxycholate protects from glycochenodeoxycholate-induced gene expression changes in perfused rat liver. Biol Chem. 2019 Nov 26;400(12):1551-1565

  [4] Yang Y, He J, Suo Y, Zheng Z, Wang J, Lv L, Huo C, Wang Z, Li J, Sun W, Zhang Y. Tauroursodeoxycholate improves 2,4,6-trinitrobenzenesulfonic acid-induced experimental acute ulcerative colitis in mice. Int Immunopharmacol. 2016 Jul;36:271-276

  [5] Ishizaki K, Kinbara S, Hirabayashi N, Uchiyama K, Maeda M. Effect of sodium tauroursodeoxycholate on phalloidin-induced cholestasis in rats. Eur J Pharmacol. 2001 Jun 1;421(1):55-60

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